Mitochondrial physiology

Authors

  • Erich Gnaiger
  • MitoEAGLE Task Group

DOI:

https://doi.org/10.26124/bec:2020-0001.v1

Keywords:

Uncoupling , SI - The International System of Units , Residual oxygen consumption, Protonmotive force, Phosphorylation efficiency, Oxygen, Oxidative phosphorylation, Normalization of rate , Respiratory states, Mitochondrial preparations, Mitochondrial marker, LEAK respiration, IUPAC, Flux control ratio, Flux, Flow, Electron transfer pathway, Coupling-control ratio, Cell count

Abstract

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery.

How to cite:

Gnaiger E - MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenergetics Communications 2020.1. https://doi.org/10.26124/bec:2020-0001.v1

Author Biography

MitoEAGLE Task Group

*Author affiliations in hyperlinks: Gnaiger E, Aasander Frostner E, Abdul KN, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, Ahn B, Alencar MB, Ali SS, Almeida A, Alton L, Alves MG, Amati F, Amoedo ND, Amorim R, Anderson EJ, Andreadou I, Antunes D, Arago M, Aral C, Arandarcikaite O, Arias-Reyes C, Armand AS, Arnould T, Avram VF, Axelrod CL, Bailey DM, Bairam A, Bajpeyi S, Bajzikova M, Bakker BM, Banni A, Bardal T, Barlow J, Bastos Sant'Anna Silva AC, Batterson PM, Battino M, Bazil JN, Beard DA, Bednarczyk P, Beleza J, Bello F, Ben-Shachar D, Bento Guida JF, Bergdahl A, Berge RK, Bergmeister L, Bernardi P, Berridge MV, Bettinazzi S, Bishop DJ, Blier PU, Blindheim DF, Boardman NT, Boetker HE, Borchard S, Boros M, Boersheim E, Borras C, Borutaite V, Botella J, Bouillaud F, Bouitbir J, Boushel RC, Bovard J, Bravo-Sagua R, Breton S, Brown DA, Brown GC, Brown RA, Brozinick JT, Buettner GR, Burtscher J, Bustos M, Calabria E, Calbet JAL, Calzia E, Cannon DT, Cano Sanchez MC, Canto Alvarez C, Cardinale DA, Cardoso LHD, Carvalho E, Casado Pinna M, Cassar S, Castelo Rueda MP, Castilho RF, Cavalcanti-de-Albuquerque J P, Cecatto C, Celen MC, Cervinkova Z, Chabi B, Chakrabarti L, Chakrabarti S, Chaurasia B, Chen Q, Chicco AJ, Chinopoulos C, Chowdhury SK, Cizmarova B, Clementi E, Coen PM, Cohen BH, Coker RH, Collin-Chenot A, Coughlan MT, Coxito P, Crisostomo L, Crispim M, Crossland H, Dahdah NR, Dalgaard LT, Dambrova M, Danhelovska T, Darveau CA, Darwin PM, Das Anibh M, Dash RK, Davidova E, Davis MS, Dayanidhi S, De Bem AF, De Goede P, De Palma C, De Pinto V, Dela F, Dembinska-Kiec A, Detraux D, Devaux Y, Di Marcello M, Di Paola FJ, Dias C, Dias TR, Diederich M, Distefano G, Djafarzadeh S, Doermann N, Doerrier C, Dong LF, Donnelly C, Drahota Z, Duarte FV, Dubouchaud H, Duchen MR, Dumas JF, Durham WJ, Dymkowska D, Dyrstad SE, Dyson A, Dzialowski EM, Eaton S, Ehinger JK, Elmer E, Endlicher R, Engin AB, Escames G, Evinova A, Ezrova Z, Falk MJ, Fell DA, Ferdinandy P, Ferko M, Fernandez-Ortiz M, Fernandez-Vizarra E, Ferreira JCB, Ferreira RMP, Ferri A, Fessel JP, Festuccia WT, Filipovska A, Fisar Z, Fischer C, Fischer MJ, Fisher G, Fisher JJ, Fontanesi F, Forbes-Hernandez TY, Ford E, Fornaro M, Fuertes Agudo M, Fulton M, Galina A, Galkin A, Gallee L, Galli GLJ, Gama Perez P, Gan Z, Ganetzky R, Gao Y, Garcia GS, Garcia-Rivas G, Garcia-Roves PM, Garcia-Souza LF, Garlid KD, Garrabou G, Garten A, Gastaldelli A, Gayen J, Genders AJ, Genova ML, Giampieri F, Giovarelli M, Glatz JFC, Goikoetxea Usandizaga N, Goncalo Teixeira da Silva R, Goncalves DF, Gonzalez-Armenta JL, Gonzalez-Franquesa A, Gonzalez-Freire M, Gonzalo H, Goodpaster BH, Gorr TA, Gourlay CW, Grams B, Granata C, Grefte S, Grilo L, Guarch ME, Gueguen N, Gumeni S, Haas C, Haavik J, Hachmo Y, Haendeler J, Haider M, Hajrulahovic A, Hamann A, Han J, Han WH, Hancock CR, Hand SC, Handl J, Hansikova H, Hardee JP, Hargreaves IP, Harper ME, Harrison DK, Hassan H, Hatokova Z, Hausenloy DJ, Heales SJR, Hecker M, Heiestad C, Hellgren KT, Henrique A, Hepple RT, Hernansanz-Agustin P, Hewakapuge S, Hickey AJ, Ho DH, Hoehn KL, Hoel F, Holland OJ, Holloway GP, Holzner L, Hoppel CL, Hoppel F, Hoppeler H, Houstek J, Huete-Ortega M, Hyrossova P, Iglesias-Gonzalez J, Indiveri C, Irving BA, Isola R, Iyer S, Jackson CB, Jadiya P, Jana Prado F, Jandeleit-Dahm K, Jang DH, Jang YC, Janowska J, Jansen KM, Jansen-Duerr P, Jansone B, Jarmuszkiewicz W, Jaskiewicz A, Jaspers RT, Jedlicka J, Jerome E, Jespersen NR, Jha RK, Jones JG, Joseph V, Juhasz L, Jurczak MJ, Jurk D, Jusic A, Kaambre T, Kaczor JJ, Kainulainen H, Kampa RP, Kandel SM, Kane DA, Kapferer W, Kapnick S, Kappler L, Karabatsiakis A, Karavaeva I, Karkucinska-Wieckowska A, Kaur S, Keijer J, Keller MA, Keppner G, Khamoui AV, Kidere D, Kilbaugh T, Kim HK, Kim JKS, Kimoloi S, Klepinin A, Klepinina L, Klingenspor M, Klocker H, Kolassa I, Komlodi T, Koopman WJH, Kopitar-Jerala N, Kowaltowski AJ, Kozlov AV, Krajcova A, Krako Jakovljevic N, Kristal BS, Krycer JR, Kuang J, Kucera O, Kuka J, Kwak HB, Kwast KE, Kwon OS, Laasmaa M, Labieniec-Watala M, Lagarrigue S, Lai N, Lalic NM, Land JM, Lane N, Laner V, Lanza IR, Laouafa S, Laranjinha J, Larsen S, Larsen TS, Lavery GG, Lazou A, Ledo AM, Lee HK, Leeuwenburgh C, Lehti M, Lemieux H, Lenaz G, Lerfall J, Li Pingan A, Li Puma L, Liang L, Liepins E, Lin CT, Liu J, Lopez Garcia LC, Lucchinetti E, Ma T, Macedo MP, Machado IF, Maciej S, MacMillan-Crow LA, Magalhaes J, Magri A, Majtnerova P, Makarova E, Makrecka-Kuka M, Malik AN, Marcouiller F, Marechal A, Markova M, Markovic I, Martin DS, Martins AD, Martins JD, Maseko TE, Maull F, Mazat JP, McKenna HT, McKenzie M, McMillan DGG, McStay GP, Mendham A, Menze MA, Mercer JR, Merz T, Messina A, Meszaros A, Methner A, Michalak S, Mila Guasch M, Minuzzi LM, Misirkic Marjanovic M, Moellering DR, Moisoi N, Molina AJA, Montaigne D, Moore AL, Moore C, Moreau K, Moreira BP, Moreno-Sanchez R, Mracek T, Muccini AM, Munro D, Muntane J, Muntean DM, Murray AJ, Musiol E, Nabben M, Nair KS, Nehlin JO, Nemec M, Nesci S, Neufer PD, Neuzil J, Neviere R, Newsom SA, Norman J, Nozickova K, Nunes S, Nuoffer JM, O'Brien K, O'Brien KA, O'Gorman D, Olgar Y, Oliveira B, Oliveira J, Oliveira MF, Oliveira MT, Oliveira PF, Oliveira PJ, Olsen RE, Orynbayeva Z, Osiewacz HD, Paez H, Pak YK, Pallotta ML, Palmeira C, Parajuli N, Passos JF, Passrugger M, Patel HH, Pavlova N, Pavlovic K, Pecina P, Pedersen TM, Perales JC, Pereira da Silva Grilo da Silva F, Pereira R, Pereira SP, Perez Valencia JA, Perks KL, Pesta D, Petit PX, Pettersen Nitschke IK, Pichaud N, Pichler I, Piel S, Pietka TA, Pinho SA, Pino MF, Pirkmajer S, Place N, Plangger M, Porter C, Porter RK, Preguica I, Prigione A, Procaccio V, Prochownik EV, Prola A, Pulinilkunnil T, Puskarich MA, Puurand M, Radenkovic F, Ramzan R, Rattan SIS, Reano S, Reboredo-Rodriguez P, Rees BB, Renner-Sattler K, Rial E, Robinson MM, Roden M, Rodrigues AS, Rodriguez E, Rodriguez-Enriquez S, Roesland GV, Rohlena J, Rolo AP, Ropelle ER, Roshanravan B, Rossignol R, Rossiter HB, Rousar T, Rubelj I, Rybacka-Mossakowska J, Saada Reisch A, Safaei Z, Salin K, Salvadego D, Sandi C, Saner N, Santos D, Sanz A, Sardao V, Sarlak S, Sazanov LA, Scaife P, Scatena R, Schartner M, Scheibye-Knudsen M, Schilling JM, Schlattner U, Schmitt S, Schneider Gasser EM, Schoenfeld P, Schots PC, Schulz R, Schwarzer C, Scott GR, Selman C, Sendon PM, Shabalina IG, Sharma P, Sharma V, Shevchuk I, Shirazi R, Shiroma JG, Siewiera K, Silber AM, Silva AM, Sims CA, Singer D, Singh BK, Skolik RA, Smenes Benedikte T, Smith J, Soares FAA, Sobotka O, Sokolova I, Solesio ME, Soliz J, Sommer N, Sonkar VK, Sova M, Sowton AP, Sparagna GC, Sparks LM, Spinazzi M, Stankova P, Starr J, Stary C, Stefan E, Stelfa G, Stepto NK, Stevanovic J, Stiban J, Stier A, Stocker R, Storder J, Sumbalova Z, Suomalainen A, Suravajhala P, Svalbe B, Swerdlow RH, Swiniuch D, Szabo I, Szewczyk A, Szibor M, Tanaka M, Tandler B, Tarnopolsky MA, Tausan D, Tavernarakis N, 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Published

2020-05-20

Issue

Section

Experimental Communications