OXPHOS coupling and uncoupling

Các tác giả

DOI:

https://doi.org/10.26124/bec.2024-0005

Từ khóa:

electron transfer capacity, LEAK respiration, mitochondria, oxidative phosphorylation

Tóm tắt

Coupling of OXPHOS is classically studied by comparing ADP-stimulated O2 flux (OXPHOS capacity P at saturating ADP and Pi concentrations) with non-phosphorylating LEAK respiration L, maintained mainly to compensate for the proton leak at high chemiosmotic potential in mitochondrial preparations supplied with fuel substrates to support mitochondrial electron transfer. However, measurement of the non-coupled electron transfer capacity E (ET capacity at collapsed chemiosmotic potential) yields additional information on coupling, since ET capacity may exceed OXPHOS capacity.

Cite:

Cardoso LHD, Gnaiger E (2024) OXPHOS coupling and uncoupling. Bioenerg Commun 2024.5. https://doi.org/10.26124/bec.2024-0005

Lượt tải xuống

Đã Xuất bản

2024-08-09

Số

Tập 2024

Chuyên mục

Living Communications

Danh mục

Giấy phép

Bản quyền (c) {copyrightHolder}

Creative Commons License

Tác phẩm này được cấp phép theo Giấy phép Creative Commons Ghi công-Phi thương mại-Không phái sinh 4.0 Quốc tế.

Cách trích dẫn

Cardoso, L. H. D., & Gnaiger, E. (2024). OXPHOS coupling and uncoupling . Bioenergetics Communications, 2024, 5. https://doi.org/10.26124/bec.2024-0005