OXPHOS coupling and uncoupling

Автор(и)

DOI:

https://doi.org/10.26124/bec.2024-0005

Ключові слова:

electron transfer capacity, LEAK respiration, mitochondria, oxidative phosphorylation

Анотація

Coupling of OXPHOS is classically studied by comparing ADP-stimulated O2 flux (OXPHOS capacity P at saturating ADP and Pi concentrations) with non-phosphorylating LEAK respiration L, maintained mainly to compensate for the proton leak at high chemiosmotic potential in mitochondrial preparations supplied with fuel substrates to support mitochondrial electron transfer. However, measurement of the non-coupled electron transfer capacity E (ET capacity at collapsed chemiosmotic potential) yields additional information on coupling, since ET capacity may exceed OXPHOS capacity.

Cite:

Cardoso LHD, Gnaiger E (2024) OXPHOS coupling and uncoupling. Bioenerg Commun 2024.5. https://doi.org/10.26124/bec.2024-0005

Завантаження

Опубліковано

2024-08-09

Номер

Том 2024

Розділ

Living Communications

Категорії

Ліцензія

Авторське право (c) 2024 Luiza Helena Daltro Cardoso, Erich Gnaiger

Creative Commons License

Ця робота ліцензується відповідно до ліцензії Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Як цитувати

Cardoso, L. H. D., & Gnaiger, E. (2024). OXPHOS coupling and uncoupling . Bioenergetics Communications, 2024, 5. https://doi.org/10.26124/bec.2024-0005