OXPHOS coupling and uncoupling

Yazarlar

DOI:

https://doi.org/10.26124/bec.2024-0005

Anahtar Kelimeler:

electron transfer capacity- LEAK respiration- mitochondria- oxidative phosphorylation

Öz

Coupling of OXPHOS is classically studied by comparing ADP-stimulated O2 flux (OXPHOS capacity P at saturating ADP and Pi concentrations) with non-phosphorylating LEAK respiration L, maintained mainly to compensate for the proton leak at high chemiosmotic potential in mitochondrial preparations supplied with fuel substrates to support mitochondrial electron transfer. However, measurement of the non-coupled electron transfer capacity E (ET capacity at collapsed chemiosmotic potential) yields additional information on coupling, since ET capacity may exceed OXPHOS capacity.

Cite:

Cardoso LHD, Gnaiger E (2024) OXPHOS coupling and uncoupling. Bioenerg Commun 2024.5. https://doi.org/10.26124/bec.2024-0005

İndir

Yayınlanmış

2024-08-09

Sayı

Cilt 2024

Bölüm

Living Communications

Kategoriler

Lisans

Telif Hakkı (c) 2024 Luiza Helena Daltro Cardoso, Erich Gnaiger

Creative Commons License

Bu çalışma Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License ile lisanslanmıştır.

Nasıl Atıf Yapılır

Cardoso, L. H. D., & Gnaiger, E. (2024). OXPHOS coupling and uncoupling . Bioenergetics Communications, 2024, 5. https://doi.org/10.26124/bec.2024-0005