OXPHOS coupling and uncoupling

Autori

DOI:

https://doi.org/10.26124/bec.2024-0005

Ključne reči:

electron transfer capacity, LEAK respiration, mitochondria, oxidative phosphorylation

Apstrakt

Coupling of OXPHOS is classically studied by comparing ADP-stimulated O2 flux (OXPHOS capacity P at saturating ADP and Pi concentrations) with non-phosphorylating LEAK respiration L, maintained mainly to compensate for the proton leak at high chemiosmotic potential in mitochondrial preparations supplied with fuel substrates to support mitochondrial electron transfer. However, measurement of the non-coupled electron transfer capacity E (ET capacity at collapsed chemiosmotic potential) yields additional information on coupling, since ET capacity may exceed OXPHOS capacity.

Cite:

Cardoso LHD, Gnaiger E (2024) OXPHOS coupling and uncoupling. Bioenerg Commun 2024.5. https://doi.org/10.26124/bec.2024-0005

Preuzimanja

Objavljeno

2024-08-09

Broj časopisa

God. 2024

Rubrika

Living Communications

Kategorije

Licenca

Sva prava zadržana (c) 2024 Luiza Helena Daltro Cardoso, Erich Gnaiger

Creative Commons License

Ovaj rad je pod Creative Commons Aуторство-Nekomercijalno-Bez prerade 4.0 Internacionalna licenca.

Kako citirati

Cardoso, L. H. D., & Gnaiger, E. (2024). OXPHOS coupling and uncoupling . Bioenergetics Communications, 2024, 5. https://doi.org/10.26124/bec.2024-0005