Tribute to Bernhard Kadenbach – Cytochrome c oxidase: from subunits to regulatory functions

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https://doi.org/10.26124/bec.2025-0003

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cytochrome c oxidase##common.commaListSeparator## subunits##common.commaListSeparator## isoforms##common.commaListSeparator## second mechanism of respiratory control##common.commaListSeparator## reactive oxygen species (ROS)

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Bernhard Kadenbach was a German biochemist whose research advanced our understanding of mitochondrial cytochrome c oxidase (Complex IV, CIV) and its regulation. In the 1980s, he discovered that mammalian CIV consists of 13 tightly bound subunits, a finding later confirmed through structural analysis. Besides the structural studies of CIV, his research focused on the role of tissue-specific isoforms of CIV subunits, its allosteric regulation by the ATP/ADP ratio, and phosphorylation mechanisms, proposing a “second mechanism of respiratory control” that modulates energy transformation and minimizes reactive oxygen species (ROS). Kadenbach’s insights into CIV regulation, tissue-specific isoforms, and metabolic control remain influential for ongoing mitochondrial research and potential therapeutic applications.

Cite:

Vogt S, Günther M, Hüttemann M (2025) Tribute to Bernhard Kadenbach – Cytochrome c oxidase: from subunits to regulatory functions. Bioenerg Commun 2025.3. https://doi.org/10.26124/bec.2025-0003

Photo of Bernhard Kadenbach

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2025-03-19

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##issue.vol## 2025

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Living Communications

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Vogt, S., Günther, M., & Hüttemann, M. (2025). Tribute to Bernhard Kadenbach – Cytochrome c oxidase: from subunits to regulatory functions. Bioenergetics Communications, 2025, 3. https://doi.org/10.26124/bec.2025-0003