The bioenergetic landscape of respiratory flux control: mapping the scope of metabolic flexibility and mitochondrial fitness

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https://doi.org/10.26124/bec2026-0005

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bioenergetic cluster analysis##common.commaListSeparator## coupling efficiency##common.commaListSeparator## electron transfer##common.commaListSeparator## excess capacity##common.commaListSeparator## leak respiration##common.commaListSeparator## oxidative capacity##common.commaListSeparator## oxidative phosphorylation##common.commaListSeparator## routine respiration##common.commaListSeparator## routine-ATP coupling ratio##common.commaListSeparator## routine-ATP control efficiency

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Contribution to MiP2026

Cite: Gnaiger E (2026) The bioenergetic landscape of respiratory flux control: mapping the scope of metabolic flexibility and mitochondrial fitness. Bioenerg Commun 2026.5 https://doi.org/10.26124/bec2026-0005

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Gnaiger E (2025) Mitochondrial respiratory function in living cells. Bioenerg Commun 2025.5. https://doi.org/10.26124/bec.2025-0005

Gnaiger E (2026) Mapping metabolic flexibility by respiratory flux control: Bioenergetic cluster analysis of mitochondrial fitness. BEC preprints 2026.5. https://doi.org/10.26124/becprep.2026-0005

Timón-Gómez A, Doerrier C, Sumbalová Z, Garcia-Souza LF, Baglivo E, Cardoso LHD, Gnaiger E (2026) Bioenergetic profiles and respiratory control in mitochondrial physiology: Precision analysis of oxidative phosphorylation. Exp Physiol 111:179-211. https://doi.org/10.1113/EP092792

Hochachka PW, Somero GN (2002) Biochemical adaptation: mechanism and process in physiological evolution. Oxford Univ Press, New York: 466 pp.

Debevec T, Longman DP, Bourgois JG (2024) Defining adaptation within applied physiology - is there room for improvement? Front Physiol 15:1459026. https://doi.org/10.3389/fphys.2024.1459026

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2026-11-12

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Living Communications

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