William J. Whelan (1924–2021): Asking the right question
The origins of glycogen and a scientific legacy
DOI:
https://doi.org/10.26124/bec2026-0002Kulcsszavak:
Glycogen syntesis, Glycogenin self-glycosilation, Bill Whelan, carbohydrate metabolismAbsztrakt
William J. Whelan was one of the leading carbohydrate biochemists of the twentieth century. His discovery of glycogenin, the self-glycosylating protein that initiates glycogen biosynthesis, resolved a longstanding paradox: glycogen synthase can extend a glucan chain but cannot create its own primer. The work completed a conceptual framework established by earlier pioneers including Carl and Gerty Cori and Luis Leloir. It also illustrates two qualities that characterized Whelan's science: recognizing a fundamental question hidden within an apparently complete pathway, and persistently testing an evidence-based interpretation despite prolonged skepticism. His influence extended beyond glycogen metabolism through scientific publishing, international biochemical organizations, education, and mentorship. Drawing on more than twenty-five years of personal acquaintance and collaboration, this article examines both his scientific contributions and the intellectual qualities that shaped them.
Cite: Azzi A (2026) William J. Whelan (1924–2021): Asking the right question: The origins of glycogen and a scientific legacy. Bioenerg Commun 2026.2. https://doi.org/10.26124/bec2026-0002
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