A BID-MTCH2 love story: Energizing mitochondria until apoptosis do them part?

Auteur/ices

  • Atan Gross Weizmann Institute of Science, IL

DOI :

https://doi.org/10.26124/bec:2024-0001

Mots-clés :

MTCH2, BID, energy metabolism, mitochondrial fusion, ER-mitochondria crosstalk, apoptosis, scramblase, insertase

Résumé

Mitochondrial carrier homolog 2 (MTCH2) is currently one of the most enigmatic mitochondrial proteins. MTCH2’s ligand is the pro-apoptotic BID protein, and the love story between these two proteins involves the regulation of diverse cellular processes including apoptosis, energy metabolism, mitochondrial dynamics, and protein insertion into the mitochondrial outer membrane. This review offers an updated progress report of these two proteins and describes our hypotheses regarding their joint mechanism of action.

Cite:

Gross A, (2024) A BID-MTCH2 love story: Energizing mitochondria until apoptosis do them part? Bioenerg Commun 2024.1. https://doi.org/10.26124/bec:2024-0001

 

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Publiée

2024-02-08

Numéro

Vol. 2024

Rubrique

Living Communications

Catégories

Licence

Certains droits réservés 2024 Atan Gross

Creative Commons License

Ce travail est disponible sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.

Comment citer

Gross, A. (2024). A BID-MTCH2 love story: Energizing mitochondria until apoptosis do them part? Bioenergetics Communications, 2024, 1. https://doi.org/10.26124/bec:2024-0001