OXPHOS coupling and uncoupling

Egileak

DOI:

https://doi.org/10.26124/bec.2024-0005

Gako-hitzak:

electron transfer capacity, LEAK respiration, mitochondria, oxidative phosphorylation

Laburpena

Coupling of OXPHOS is classically studied by comparing ADP-stimulated O2 flux (OXPHOS capacity P at saturating ADP and Pi concentrations) with non-phosphorylating LEAK respiration L, maintained mainly to compensate for the proton leak at high chemiosmotic potential in mitochondrial preparations supplied with fuel substrates to support mitochondrial electron transfer. However, measurement of the non-coupled electron transfer capacity E (ET capacity at collapsed chemiosmotic potential) yields additional information on coupling, since ET capacity may exceed OXPHOS capacity.

Cite:

Cardoso LHD, Gnaiger E (2024) OXPHOS coupling and uncoupling. Bioenerg Commun 2024.5. https://doi.org/10.26124/bec.2024-0005

Deskargak

Argitaratua

2024-08-09

Zenbakia

Libk. 2024

Atala

Living Communications

Kategoriak

Lizentzia

Egile-eskubideak 2024 Luiza Helena Daltro Cardoso, Erich Gnaiger

Creative Commons License

Lan hau Creative Commons Aitortu-EzKomertziala-LanEratorririkGabe 4.0 Nazioarteko Lizentziapean dago argitaratuta.

Aipuak nola egin

Cardoso, L. H. D., & Gnaiger, E. (2024). OXPHOS coupling and uncoupling . Bioenergetics Communications, 2024, 5. https://doi.org/10.26124/bec.2024-0005