Cyclophilin D modulates mitochondrial bioenergetics, but its deficiency does not enhance cell viability following mitochondrial transplantation

Authors

  • Elisa Zamprogno Department of Medicine, University of Udine, Italy
  • Gabriele Coluccino Department of Medicine, University of Udine, Italy
  • Giada Carpi Departmet of Medicine, University of Udine, Italy
  • Marina Comelli Department of Medicine, University of Udine, Italy
  • Sandro Sponga Division of Cardiac Surgery, Department of Cardiothoracic and Vascular Disease, University of Siena, Italy
  • Antonio Paolo Beltrami Department of Medicine, University of Udine, Italy; Academic Hospital of Udine, ASUFC, Italy
  • Giovanna Lippe Department of Medicine, University of Udine, Italy

DOI:

https://doi.org/10.26124/bec2026-0004

Keywords:

Cyclophilin D , mitochondrial transplantation

Abstract

Contribution to MiP2026

Cite: Zamprogno E, Coluccino G, Carpi G, Comelli M, Sponga S, Beltrami AP, 3, Lippe G (2026) Cyclophilin D modulates mitochondrial bioenergetics, but its deficiency does not enhance cell viability following mitochondrial transplantation. Bioenerg Commun 2026.4. https://doi.org/10.26124/bec2026-0004

References

Coluccino G et al (2023) Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration? Biomolecules. 13(8):1265 https://doi.org/10.3390/biom13081265.

Coluccino G et al (2024) N-terminal cleavage of cyclophilin D boosts its ability to bind F-ATP synthase. Commun Biol. 7(1):1486 https://doi.org/10.1038/s42003-024-07172-8.

Giorgio V et al (2009) Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex. Journal of Biological Chemistry. 284(49):33982–33988 https://doi.org/10.1074/jbc.M109.020115.

Gnaiger E - MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenergetics Communications. 2020 https://doi.org/10.26124/BEC:2020-0001.V1.

Acin‐Perez R et al (2023) Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies. EMBO J. 42(10):EMBJ2022111699 https://doi.org/10.15252/embj.2022111699.

Carraro M et al (2020) The Unique Cysteine of F-ATP Synthase OSCP Subunit Participates in Modulation of the Permeability Transition Pore. Cell Reports. 32(9):108095 https://doi.org/10.1016/j.celrep.2020.108095.

Di Lisa F et al (2001) Opening of the Mitochondrial Permeability Transition Pore Causes Depletion of Mitochondrial and Cytosolic NAD⁺ and Is a Causative Event in the Death of Myocytes in Postischemic Reperfusion of the Heart. Journal of Biological Chemistry. 276(4):2571–2575 https://doi.org/10.1074/jbc.M006825200.

Downloads

Published

2026-11-11

Issue

Vol. 2026

Section

Living Communications

Categories

License

Copyright (c) 2026 Elisa Zamprogno, Gabriele Coluccino, Giada Carpi, Marina Comelli, Sandro Sponga, Antonio Paolo Beltrami, Giovanna Lippe

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Zamprogno, E., Coluccino, G., Carpi, G., Comelli, M., Sponga, S., Beltrami, A. P., & Lippe, G. (2026). Cyclophilin D modulates mitochondrial bioenergetics, but its deficiency does not enhance cell viability following mitochondrial transplantation. Bioenergetics Communications, 2026, 4. https://doi.org/10.26124/bec2026-0004