Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older adult women

Stephanie Heimler; Howard  Phang; Jaclyn Bergstrom; Gargi Mahapatra; Stephen Dozier; Erich Gnaiger; Anthony Molina

doi:10.26124/bec:2022-0002

Autors/ores

Stephanie Heimler University of California San Diego School of Medicine, La Jolla, CA, USA https://orcid.org/0000-0002-5855-6525 ##orcid.unauthenticated##
Howard Phang University of California San Diego School of Medicine, La Jolla, CA, USA https://orcid.org/0000-0002-5064-4272 ##orcid.unauthenticated##
Jaclyn Bergstrom University of California San Diego School of Medicine, La Jolla, CA, USA
Gargi Mahapatra Wake Forest Baptist Medical Center, Winston-Salem, NC, USA https://orcid.org/0000-0003-2363-4092 ##orcid.unauthenticated##
Stephen Dozier University of California San Diego School of Medicine, La Jolla, CA, USA
Erich Gnaiger Oroboros Instruments, Innsbruck, AT https://orcid.org/0000-0003-3647-5895 ##orcid.unauthenticated##
Anthony Molina University of California San Diego School of Medicine, La Jolla, CA, USA https://orcid.org/0000-0003-3647-5895 ##orcid.unauthenticated##

DOI:

https://doi.org/10.26124/bec:2022-0002

Paraules clau:

platelets, resting metabolic rate (RMR), cardiopulmonary exercise testing (CPET), OXPHOS capacity, electron transfer capacity, inverted regression analysis

Resum

This study investigates relationships between platelet mitochondrial bioenergetics and resting metabolic rate (RMR), body composition, and exercise fitness in older adult women. We report positive correlations between peak respiratory exchange ratio (RER) and RMR with five measures of platelet respiration, supporting the premise that blood cells can be utilized to report on mitochondrial function associated with physical health and fitness. Identifying mechanisms associated with physical performance among older adults supports the development of reliable biomarkers of healthy aging and can advance the development of efficacious interventions.

Cite:

Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina AJA (2022). Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older women. Bioenerg Commun 2022.2. https://doi.org/10.26124/bec:2022-0002

Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older adult women

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