A BID-MTCH2 love story: Energizing mitochondria until apoptosis do them part?

Authors

  • Atan Gross Weizmann Institute of Science, IL

DOI:

https://doi.org/10.26124/bec:2024-0001

Keywords:

MTCH2, BID, energy metabolism, mitochondrial fusion, ER-mitochondria crosstalk, apoptosis, scramblase, insertase

Summary

Mitochondrial carrier homolog 2 (MTCH2) is currently one of the most enigmatic mitochondrial proteins. MTCH2’s ligand is the pro-apoptotic BID protein, and the love story between these two proteins involves the regulation of diverse cellular processes including apoptosis, energy metabolism, mitochondrial dynamics, and protein insertion into the mitochondrial outer membrane. This review offers an updated progress report of these two proteins and describes our hypotheses regarding their joint mechanism of action.

Cite:

Gross A, (2024) A BID-MTCH2 love story: Energizing mitochondria until apoptosis do them part? Bioenerg Commun 2024.1. https://doi.org/10.26124/bec:2024-0001

 

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Published

2024-02-08

Issue

Vol. 2024

Section

Living Communications

License

Copyright (c) 2024 Atan Gross

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.